Also known as
SAM-e is a dietary supplement and common enzymatic co-factor involved in methyl group transfers, transsulfuration, and aminopropylation. SAM-e is produced and mainly consumed in the liver, where it is extensively used for detoxication purposes. More than 40 methyl transfers from SAM-e are known, involving various substrates such as nucleic acids, proteins, lipids, neurotransmitters, hormones, and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase.
Recommended amount per dose is 500-1000 mg, or 1-2 size '00' capsules.
SAM-e exerts the majority of its effects by providing methyl group donors to the body, this occurs mostly in the liver to support detoxification, but also occurs elsewhere where these groups are used for numerous process involving metabolism and activation/deactivation of many substances. SAM-e has been studied for a possible role in depression, and may be a viable mood lifter for some individuals. Concurrent administration with an MAO inhibitor like Curcumin or Rhodiola rosea is linked to an enhancement of this effect, while neurotransmitter based amino acids such as tyrosine, phenylalanine, 5-htp, and l-dopa may also play additional complimentary roles.
Do not consume without knowing an accurate dosage. A milligram scale is highly recommended.
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