Puerarin (Pueraria lobata isolate)

Puerarin (Pueraria lobata isolate)

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Also known as
Puerarin, Pueraria lobata, Ge Gen, Japanese arrowroot                        

Standardized extract of kudzu root, specified to a 98% concentration of puerarin.

Introduction
Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata. Puerarin has a wide range of biological activities such as vasodilation, cardioprotection, neuroprotection, antioxidation, anti-inflammation, alleviating pain, promoting bone formation, inhibition of alcohol intake, and attenuating insulin resistance.

Constituents
98% pure Puerarin

Use
Recommended amount per dose is 500-1000 mg, or 1-2 filled size '00' capsules, three times daily. Best taken with a small amount of food for proper absorption.

Summary
Puerarin is a very useful isoflavone and general health supplement, showing promise in assisting with issues relating to circulation, behaving as a vasodilator, and more specifically as an anti-vasoconstrictive agent, both in the body and cerebral. Puerarin also shows a glucose reducing action, increasing insulin levels and causing a secretion of b-endorphin, a well known marker of satiety. Puerarin has also been shown to protect against neuronal loss, preventing apoptosis (cell death) of dopaminergic neurons. Puerarin also inhibited Aβ-induced neurotoxicity, a common marker of neurodegeneration, which also happens to be related to suppression of apoptosis. Puerarin also shows promise in assisting in bone formation and healing, and significantly increases the pain threshold response, operating as a P2X3 and P2X7 inhibitor and downregulating the activity of these receptors, which function as hyperalgesic sensitizers in response to burn injuries. Puerarin also shows numerous anti-inflammatory activities such as reducing the levels of IL-1β, TNF-α, IL-6, prostaglandin E 2, and NO, and blocked the activation of NF-κB and phosphorylation of MAPKs raised by LPS, a marker of neural inflammation that is activated by both the pain response and by opiate type drugs. Puerarin, and kudzu root itself also show promise in assisting with addiction, specifically alcohol where the compound has been shown to reduce alcohol withdrawal related anxieties. This is believed to be due to actions on the benzodiazepine and 5ht receptors, specifically a blocking of 5ht2c receptor and an activation of the 5ht1a receptor, and either a low affinity agonism or antagonism of the benzodiazepine site, causing a normalization type state of the receptor to occur.

Overall, puerarin shows numerous beneficial effects and is a promising herbal dietary supplement for a number of reasons.



Precautions
Puerarin shows estrogenic activity and may be contraindicated in those at risk of developing breast and other cancers. Puerarin should not be taken by pregnant or nursing mothers. Speak to your doctor before use.

Do not consume without knowing an accurate dosage. A milligram scale is highly recommended.


Disclaimer
The statements made on this website have not been evaluated by the FDA (U.S. Food & Drug Administration). Our products are not intended to diagnose, cure or prevent any disease. For education and research purposes only. Customers must be over 18 years of age to purchase anything from this site. Research all items before using.